The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease

Sinai Health System’s Rebecca MacDonald Centre for Arthritis and Autoimmune Disease houses Canada’s most advanced clinical management and research platform for the most severe and potentially life-threatening autoimmune diseases namely rheumatoid arthritis (RA), scleroderma and vasculitis.
Via at least 15,000 patient encounters each year, the Centre cares for patients at every stage of disease even helping to prevent the onset of inflammation and disease in healthy people at high risk for RA.
Through our bench to bedside approach, we are improving the lives of people with autoimmune inflammatory conditions.

World-leading scientific power

Some anti-inflammatory medications developed for rheumatoid arthritis are now being used to treat people with heart disease and stroke. Our arthritis discoveries could give doctors new tools to control rheumatic disease and also many other chronic, inflammatory diseases.
Edward C. Keystone, MD, FRCPC
Dr. Ed Keystone is the Director of the Rebecca MacDonald Centre for Arthritis and Autoimmune Disease. He is a world-recognized leader and clinical care and clinical research into rheumatoid arthritis and autoimmune diseases. His work explores the cellular and molecular events that contribute to both the early and late phases of RA as well as the inflammatory subset of osteoarthritis (OA).
Katherine Siminovitch, MD, FRCPC
Dr. Katherine Siminovitch is a Senior Investigator at Sinai Health’s Lunenfeld-Tanenbaum Research Institute, and the Canada Research Chair in the Mechanisms Regulating Immunologic Disease. An acclaimed leader in genomic medicine, Dr. Siminovitch studies the molecular mechanisms that underpin the development of immunologic disease. Through her research, Dr. Siminovitch aims to discover new knowledge that improves clinical care and outcomes for people with autoimmune diseases.