Scientists discover link between autism and cognitive impairment
Jan. 29, 2020
A tiny gene fragment may play a pivotal role in why some people with autism also develop mental disabilities, according to new research from scientists at Sinai Health and the University of Toronto. Their study, published in the journal Molecular Cell, identifies a short gene segment, or microexon, that is crucial for brain development and information processing. In this article, LTRI’s Sabine Cordes describes how an absence of this segment leads to altered social behaviour in mice, as well as learning and memory deficits.
Researchers discover new tool for investigating brain disorders, including dementia and depression
Jan. 22, 2020
A team of scientists from Canada, the UK and US has discovered a new compound that could lead to better treatments for a host of serious brain disorders. Their study, published recently in the journal Nature Communications, is an important step forward for studying Alzheimer's, epilepsy, stroke and even Parkinson's disease.
Marvelle Koffler’s legacy of philanthropy and care
Jan. 14, 2020
Sinai Health mourns the passing and celebrates the legacy of Marvelle Koffler (z"l), a visionary philanthropist whose generosity has had an immeasurable impact on breast cancer patients at Mount Sinai Hospital. Marvelle turned her own breast cancer journey into a mission to help others. By creating the Marvelle Koffler Breast Centre at Mount Sinai the first truly multidisciplinary centre of its kind in Canada she ensured that patients would receive world-class breast cancer treatment in a comfortable and caring environment.
Sinai Health researchers awarded grant to fight vision loss
Jan. 14, 2020
Retinitis pigmentosa causes gradual vision loss and is one of the most common inherited retinal diseases. LTRI researchers Rod Bremner and Daniel Schramek have a vision to discover what’s behind it, thanks to $300,000 in new grant support from Fighting Blindess Canada. “We’re honored to be selected by Fighting Blindness Canada and commend their dedication to finding new treatments for blinding eye diseases,” Bremner said.
Dr. Daniel Drucker honoured with 2020 Baxter Prize for diabetes impact
Jan. 14, 2020
Daniel Drucker, an award-winning researcher whose work led to the development of two new treatments for Type 2 diabetes, is being honoured by the Endocrine Society with the 2020 Baxter Prize. “I’m honoured to be recognized by the Endocrine Society, and my success wouldn’t have been possible without the support of my mentors and teammates,” Drucker said. “I became an entrepreneur because of my passion for endocrine discovery and the potential to save lives by developing novel therapies.”
New study sheds light on why non-smokers develop lung cancer
Jan. 13, 2020
A new study out by Sinai Health researcher Rayjean Hung looks at why otherwise healthy, non-smokers develop lung cancer -- and her findings suggest the reason may lie in the immune system. The results were published this month in the journal Nature Communications and were featured as one of the Editors’ Highlights.
Congratulations to our first Sinai 50/50 draw winner!
Jan. 6, 2020
We are delighted to announce the winner of Sinai Health Foundation’s new 50/50 lottery is Sean Hannon, a long-time member of the Sinai Health family and a project manager helping to bring our ambitious Renew Sinai Phase 3a project to life. Please join us in congratulating Sean on his exciting win!
SREMI Inaugural Research Chair in Geriatric Emergency Medicine announced
Dec. 9, 2019
A leading researcher in recognizing and preventing delirium in older patients is joining Sinai Health as its inaugural SREMI Research Chair in Geriatric Emergency Medicine. For Dr. Jacques Lee, it’s all about looking past the blue gown. “There can be an assumption that confusion is normal in older people,” Lee said. “You see an older person with grey hair in a blue gown and they’re a little confused, but we’ve stripped them of their context.”
Taking a closer look at the science behind Sinai
Dec. 2, 2019
Health care is a team sport and our researchers are the ones changing the game. For the month of December, Sinai Health is celebrating the Lunenfeld-Tanenbaum Research Institute, located inside Mount Sinai Hospital. It has been a powerhouse for scientific discovery for almost 35 years and the people who work there are nothing short of inspiring. Learn more about the exceptional work done at LTRI with our series Research Wrap-Up.
Researchers discover Vitamin C may impact fertility for generations
Oct. 28, 2019
Dr. Miguel Ramalho-Santos, a senior investigator at Sinai Health’s Lunenfeld-Tanenbaum Research Institute, found the diet of expectant mothers could play an important role in her baby’s own fertility later in life. Published in the journal Nature, this study shows how the diet of pregnant women may be linked to diseases their children develop later in life, and genetics alone do not determine how a fetus forms. The study was led by graduate student Stephanie DiTroia. “This is an example of how basic biology works in mysterious ways and has the power to unveil unexpected insights,” said Dr. Ramalho-Santos.
New study uses yeast to examine how genes work together in drug resistance
Oct. 23, 2019
A Toronto researcher is using Baker’s yeast as a model system to investigate how groups of genes interact to alter a cell’s resistance to drugs. Frederick Roth, a senior scientist at the Lunenfeld-Tanenbaum Research Institute at Sinai Health, used yeast to demonstrate how different gene combinations can change a cell’s resistance or sensitivity to drugs. His findings have been published in the journal Cell Systems.